In Milan, public transportation will shut down from 8:45 A.M. to 3 P.M., then again from 6 P.M. to 7:45 P.M.
This time, it's "only" for 8 hours, so your work day shouldn't be too disrupted.
Plan to catch a burger and some time admiring the exterior of the Duomo after work.
(Can hardly add my usualy "Enjoy!," can I?)